Beilstein J. Org. Chem.2012,8, 2060–2066, doi:10.3762/bjoc.8.231
highly active against KB-3-1 cells and exhibited an IC50 value in the low picomolar range. However, the replacement of the 3-chloro-4-methoxyphenyl-substituent in unit B by a pentafluorophenyl moiety resulted in a significant loss of activity.
Keywords: antimitoticdrug; cytotoxicity; depsipeptide
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Graphical Abstract
Figure 1:
Structures of cryptophycin-1 (1) and -52 (2).